Zithromax contain Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin prevents bacteria from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA.
It is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, strep throat,pneumonia, typhoid, gastroenteritis, bronchitis and sinusitis. In recent years, it has been used primarily to prevent bacterial infections in infants and those with weaker immune systems. It is also successful against certain sexually transmitted infections, such as non gonococcal urethritis, chlamydia, and cervicitis. Some studies have indicated it also to be effective against late-onset asthma, but these findings are controversial and not widely accepted.
This drug is used to treat many different infections, including acute otitis media, non streptococcal bacterial pharyngitis, gastrointestinal infections such as traveler’s diarrhea, respiratory tract infections such as pneumonia, cellulitis, babesiosis, Bartonellainfection, chancroid, cholera, donovanosis, leptospirosis, Lyme disease, malaria, Mycobacterium avium complex disease, Neisseriameningitis, pelvic inflammatory disease, pertussis, scrub typhus, toxoplasmosis, and salmonellosis. It is used to prevent bacterial endocarditis and some sexually transmitted infections. It is also effective against localized dental infections, uncomplicated skin and skin structure infections, urethritis and cervicitis and also genital ulcer disease.
It is used as a second line treatment for strep throat and for those allergic to penicillin. It has a similar antimicrobial spectrum to erythromycin, but is more successful against certain Gram-negative bacteria, in particular, Haemophilus influenzae (although it would not be the first choice of treatment in this infection). Azithromycin resistance has been described and is endemic in many areas. Long-term use in treating Staphylococcus aureus infections with it may increase bacterial resistance to this and other macrolide antibiotics. Azithromycin has been shown to be effective against malaria when used in combination with artesunate or quinine; the optimal dose for this is not yet known.