Allopurinol Zyloprim that is used for treating increased blood levels of uric acid and preventing gout increases azathioprine levels in the blood which may increase the risk of side effects from azathioprine .Therefore it is important to reduce the dose of azathioprine by approximately 13 to 14 in patients taking allopurinol. The use of angiotensinconverting enzyme ACE inhibitors to control high blood pressure in patients taking azathioprine has been reported to induceanemia low levels of red blood cells and severe leukopenia low levels of white blood cells. Azathioprine reduces blood levels of the blood thinnerwarfarin. Coumadin and thus may reduce the blood thinning effect of warfarin Safety and efficacy of azathioprine in children have not been established.
Side effects :
- Super added bacterial, viral or fungal infections.
- Possible development of lymphoma.
- Vomiting, GI hemorrhage and perforation, acne, rash, alopecia, dizziness, pancreatitis, hepatitis, pulmonary fibrosis.
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